This interdisciplinary, cross-cultural study seeks to understand pathways for sustaining flourishing mental health among caregivers of orphans living in four countries (India, Kenya, Ethiopia, and Cambodia) and of four religious traditions (Christianity, Islam, Hinduism, and Buddhism). This qualitative and quantitative study includes interviews, surveys, and diaries. The findings aim to advance theoretical concepts of stress, coping, and well-being; to inform the measurement of virtue; and to provide practical guidance on how caregivers in challenging contexts can flourish.